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2004

1. Reductive and catalytic monoalkylation of primary amines using nitriles as an alkylating reagent.
   H. Sajiki, T. Ikawa, K. Hirota.
   Org. Lett.., 6, 4977-4980 (2004)
2. Complete Replacement of H₂ by D₂ via Pd/C-Catalyzed H/D Exchange Reaction.
   H. Sajiki, T. Kurita, H. Esaki, F. Aoki, T. Maegawa, K. Hirota.
   Org. Lett, 6, 3521-3523 (2004)
3. Solvent-modulated Pd/C-catalyzed deprotection of silyl ethers and chemoselective hydrogenation.
   T. Ikawa, K. Hattori, H. Sajiki, K. Hirota.
   Tetrahedron, 60, 6901-6911(2004)
4. Unexpected deprotection of silyl and THP ethers induced by serious disparity in the quality of Pd/C catalysts and elucidation of the mechanism.
   T. Ikawa, H. Sajiki, K. Hirota.
   Tetrahedron, 60, 6189-6195 (2004)
5. Efficient C-H/C-D Exchange Reaction on the Alkyl Side Chain of Aromatic CompoundsUsing Heterogeneous Pd/C in D₂O.
   H. Sajiki, F. Aoki, H. Esaki, T. Maegawa, K. Hirota.
   Org. Lett., 6, 1485-1487 (2004)
6. Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities.
   A. Kurimoto, T. Ogino, S. Ichii, Y. Isobe, M. Tobe, H. Ogita, H. Takaku, H. Sajiki, K. Hirota.; H. Kawakami.
   Bioorganic & medicinal chemistry, 12, 1091-1099 (2004)

2003

1. Synthesis and Structure-Activity Relationships of 2-Substituted-8-hydroxyadenine derivatives as Orally Available Interferon Inducers without Emetic Side Effect,
   Yoshiaki Isobe, Masanori Tobe, Horuhisa Ogita, Ayumu Kurimoto, Tetsuo Ogino, Hajime Kawakami, Haruo Takaku, Hironao Sajiki, Kosaku Hirota and Hideya Hayashi
   Bioorg. Med. Chem., 11, 3641-3647 (2003).
2. Preparation of Silk Fibroin-supported Pd(0) Catalyst for Chemoselective Hydrogenation: Reduction of Palladium(II) Acetate by Methanol on the Protein.
   Hironao Sajiki, Takashi Ikawa, Hiromi Yamada, Kozo Tsubouchi, Kosaku Hirota
   Tetrahedron Lett., 44, 171-174 (2003).
3. A Novel Chemical Modification at the 5-Position of Uridine Derivatives.
   Hironao Sajiki, Akira Yamada, Kanoko Yasunaga, Takashi Tsunoda, Mumen F. A. Amer, Kosaku Hirota
   Tetrahedron Lett., 44, 2179-2181 (2003)
4. Synthesis and structure-activity relationships of 2-amino-8-hydroxyadenines as orally active interferon inducing agents.
   A. Kurimoto, T. Ogino, S. Ichii, Y. Isobe, M. Tobe, H. Ogita, H. Takaku, H. Sajiki, K. Hirota, H. Kawakami.
   Bioorganic & Medicinal Chemistry, 11, 5501-5508 (2003)
5. Markedly chemoselective hydrogenation with retention of benzyl ester and N-Cbz functions using a heterogeneous Pd-fibroin catalyst.
   H. Sajiki, T. Ikawa, K. Hirota.
   Tetrahedron Lett., 44, 8437-8439 (2003)
6. Significant supplier-dependent disparity in catalyst activity of commercial Pd/C toward the cleavage of triethylsilyl ether.
   H. Sajiki, T. Ikawa, K. Hirota.
   Tetrahedron Lett., 44, 7407-7410 (2003)
7. Synthesis of 6-substituted 9-benzyl-8-hydroxypurines with potential interferon-inducing activity.
   K. Kazaoka, H. Sajiki, K. Hirota.
   Chemical & Pharmaceutical Bulletin, 51, 608-611 (2003)
8. Synthesis and biological evaluation of 2,8-disubstituted 9-benzyladenines: discovery of 8-mercaptoadenines as potent interferon-inducers.
   K. Hirota, K. Kazaoka, H. Sajiki.
   Bioorganic & Medicinal Chemistry, 11, 2715-2722 (2003)
9. Efficient synthesis of 2,9-disubstituted 8-hydroxyadenine derivatives.
   K. Hirota, K. Kazaoka, I. Niimoto, H. Sajiki.
   Organic & Biomolecular Chemistry, 1, 1354-1365 (2003)
10. Pd/C-catalyzed chemoselective hydrogenation in the presence of a phenolic MPM protective group using pyridine as a catalyst poison.
    H. Sajiki, K. Hirota.
    Chemical & Pharmaceutical Bulletin, 51, 320-324 (2003)
11. A remarkable solvent effect toward the Pd/C-catalyzed cleavage of silyl ethers.
    H. Sajiki, T. Ikawa, K. Hattori, K. Hirota, Kosaku.
    Chem. Comm., 5, 654-655 (2003)

2002

1. Regioselective BH₃-hydride Reduction of Inosine Derivatives.
   Kosaku Hirota, Hironao Sajiki, Ryuji Hattori, Yasunari Monguchi, Genzoh Tanabe, Osamu Muraoka
   Tetrahedron Lett., 43, 653-655 (2002)
2. A novel C-C bond formation at the 5-position of uridine derivatives.
   H. Sajiki, A. Yamada, K. Yasunaga, T. Tsunoda, Amer, Mumen F. A.; K. Hirota.
   Nucleic Acids Research Supplement., 2 (Twenty-ninth Symposium on Nucleic Acids Chemistry), 13-14 (2002)
3. Discovery of 8-Hydroxyadenines as a Novel Type of Interferon Inducer.
   K. Hirota, K. Kazaoka, I. Niimoto, H. Kumihara, H. Sajiki, Y. Isobe, H. Takaku, M. Tobe, H. Ogita, T. Ogino, S. Ichii, A. Kurimoto, H. Kawakami.
   Journal of Medicinal Chemistry, 45, 5419-5422 (2002)
4. Complete and truly catalytic degradation method of PCBs using Pd/C-Et₃N system under ambient pressure and temperature.
   H. Sajiki, A. Kume, K. Hattori, H. Nagase, K. Hirota.
   Tetrahedron Lett., 43, 7251-7254 (2002)